Schisandra čínská neboli klanopraška čínská (Schisandra chinensis) se využívá v tradiční čínské medicíně pro své antimikrobiální, antivirové, antimykotické a antioxidační účinky. Hlavní účinnou složkou této rostliny jsou dibenzocyklooktadienové lignany. Bylo zjištěno, že tyto lignany blokují membránové ABC-transportéry, které jsou zodpovědné za mnohočetnou lékovou rezistenci při léčbě nádorů cytostatiky.

Použitá a citovaná literatura:
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HANCKE, J.L., R.A. BURGOS, F. AHUMADA, Weici TANG a Gerhard EISENBRAND. Schisandra chinensis (Turcz.) Baill. Fitoterapia [online]. 1999, vol. 70, issue 5, s. 903-917 [cit. 2015-02-19]. DOI: 10.1007/978-3-642-73739-8_111.
CHIU, Po Yee, Man Ho TANG, Duncan H.F. MAK, Michel K.T. POON a Kam Ming KO. Hepatoprotective mechanism of schisandrin B: role of mitochondrial glutathione antioxidant status and heat shock proteins. Free Radical Biology and Medicine [online]. 2003, vol. 35, issue 4, s. 368-380 [cit. 2015-02-19]. DOI: 10.1016/s0891-5849(03)00274-0.
CHIU, Po Yee a Kam Ming KO. Schisandrin B protects myocardial ischemia-reperfusion injury partly by inducing Hsp25 and Hsp70 expression in rats. Molecular and Cellular Biochemistry [online]. 2004, vol. 266, 1/2, s. 139-144 [cit. 2015-02-19]. DOI: 10.1023/b:mcbi.0000049151.79238.30.
LAPEV, I. I. Result of treatment of chronic gastritis with Schisandra chinensis. Klin med. 1958, vol. 36, s. 109-112.
LI, P. C., M. K. T. POON a K. M. KO. Schisandra Chinensis – dependent Myocardial Protective Action of Sheng-Mai-San in Rats. The American Journal of Chinese Medicine [online]. 1996, vol. 24, 03n04, s. 255-262 [cit. 2015-02-19]. DOI: 10.1142/s0192415x96000311.
PAN, Qiangrong, Qinghua LU, Kun ZHANG a Xun HU. Dibenzocyclooctadiene lingnans: a class of novel inhibitors of P-glycoprotein. Cancer Chemotherapy and Pharmacology [online]. 2005, vol. 58, issue 1, s. 99-106 [cit. 2015-02-19]. DOI: 10.1007/s00280-005-0133-1.
QIANGRONG, Pan, Tao WANG, Qinghua LU a Xun HU. Schisandrin B — A novel inhibitor of P-glycoprotein. Biochemical and Biophysical Research Communications [online]. 2005, vol. 335, issue 2, s. 406-411 [cit. 2015-02-19]. DOI: 10.1016/j.bbrc.2005.07.097.
RHYU, M.R., E.-Y. KIM, B.-K. YOON, Y.J. LEE a S.-N. CHEN. Aqueous extract of Schizandra chinensis fruit causes endothelium-dependent and -independent relaxation of isolated rat thoracic aorta. Phytomedicine [online]. 2006, vol. 13, 9-10, s. 651-657 [cit. 2015-02-19]. DOI: 10.1016/j.phymed.2006.02.003.
SALBE, A.D. a L.F. BJELDANES. The effects of dietary brussels sprouts and Schizandra chinensis on the xenobiotic-metabolizing enzymes of the rat small intestine. Food and Chemical Toxicology [online]. 1985, vol. 23, issue 1, s. 57-65 [cit. 2015-02-19]. DOI: 10.1016/0278-6915(85)90221-2.
SLANINA, J. Biologická a farmakologická aktivita lignanů. Chemické Listy. 2000, č. 94, s. 111-116.
SLANINOVÁ, I., L. BŘEZINOVÁ, L. KOUBÍKOVÁ a J. SLANINA. Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells – Study of structure–activity relationship. Toxicology in Vitro [online]. 2009, vol. 23, issue 6, s. 1047-1054 [cit. 2015-02-19]. DOI: 10.1016/j.tiv.2009.06.008.

Schisandra chinensis has been used in traditional Chinese medicine for its antimicro­bial, antiviral, antimycotic and antioxida­tive effects. The main active compounds are dibenzocyclooctadiene lignans, which inhibit membrane ABC-transporters, re­sponsible for the multi-drug resistance of cancer cells during their treatment by cyto­statics.